Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355406 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2ACE2NPSR1KDM4EL3MBTL1 | |
| SCHEMBL14355396 | 0.93 | KDM4E (0.44) | SMN1; SMN2ACE2KDM4EL3MBTL1PRMT5 | |
| SCHEMBL14355400 | 0.93 | KDM4E (0.44) | SMN1; SMN2ACE2KDM4EL3MBTL1PRMT5 | |
| SCHEMBL13648685 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2ACE2NPSR1KDM4EL3MBTL1 | |
| SCHEMBL13648686 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2ACE2NPSR1KDM4EL3MBTL1 | |
| SCHEMBL14355398 | 0.88 | DRD4 (0.54) | ABCB1TSHRGAAATM | |
| SCHEMBL14355401 | 0.88 | DRD4 (0.54) | ABCB1TSHRGAAATM | |
| SCHEMBL13655128 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2ACE2NPSR1KDM4EL3MBTL1 | |
| SCHEMBL13655353 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2ACE2NPSR1KDM4EL3MBTL1 | |
| SCHEMBL13648688 | 0.83 | KDM4E (0.44) | SMN1; SMN2ACE2KDM4EPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291624-B2 | CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents | BAYER SCHERING PHARMA AG (DE) | 2007-11-06 | — | — | US | disclosed |
| US-7291624-B2 | CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents | BAYER SCHERING PHARMA AG (DE) | 2007-11-06 | — | — | US | disclosed |