Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355396 | 1.00 | KDM4E (0.44) | KDM4EGLATP53SMN1; SMN2PRMT5 | |
| SCHEMBL14355406 | 0.93 | SMN1; SMN2 (0.48) | KDM4ETP53SMN1; SMN2PRMT5WDR77 | |
| SCHEMBL14355393 | 0.93 | SMN1; SMN2 (0.48) | KDM4ETP53SMN1; SMN2PRMT5WDR77 | |
| SCHEMBL13648688 | 0.91 | KDM4E (0.44) | KDM4EGLATP53SMN1; SMN2PRMT5 | |
| SCHEMBL13648687 | 0.91 | KDM4E (0.44) | KDM4EGLATP53SMN1; SMN2PRMT5 | |
| SCHEMBL13655173 | 0.86 | KDM4E (0.49) | KDM4EGLATP53SMN1; SMN2PRMT5 | |
| SCHEMBL13655190 | 0.86 | KDM4E (0.49) | KDM4EGLATP53SMN1; SMN2PRMT5 | |
| SCHEMBL14355398 | 0.86 | DRD4 (0.54) | — | |
| SCHEMBL14355401 | 0.86 | DRD4 (0.54) | — | |
| SCHEMBL6643046 | 0.84 | CDK4 (0.57) | KDM4EGLABRD4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291624-B2 | CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents | BAYER SCHERING PHARMA AG (DE) | 2007-11-06 | — | — | US | disclosed |
| US-7291624-B2 | CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents | BAYER SCHERING PHARMA AG (DE) | 2007-11-06 | — | — | US | disclosed |