Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355401 | 1.00 | DRD4 (0.54) | DRD4GAADRD2KMT2AMEN1 | |
| SCHEMBL13648389 | 0.92 | DRD4 (0.54) | DRD4GAADRD2KMT2AMEN1 | |
| SCHEMBL13648689 | 0.92 | DRD4 (0.54) | DRD4GAADRD2KMT2AMEN1 | |
| SCHEMBL13648690 | 0.92 | DRD4 (0.54) | DRD4GAADRD2KMT2AMEN1 | |
| SCHEMBL14355393 | 0.88 | SMN1; SMN2 (0.48) | GAAATMABCB1TSHR | |
| SCHEMBL14355406 | 0.88 | SMN1; SMN2 (0.48) | GAAATMABCB1TSHR | |
| SCHEMBL13655055 | 0.88 | DRD4 (0.60) | DRD4GAADRD2KMT2AMEN1 | |
| SCHEMBL13655057 | 0.88 | DRD4 (0.60) | DRD4GAADRD2KMT2AMEN1 | |
| SCHEMBL14355396 | 0.86 | KDM4E (0.44) | — | |
| SCHEMBL14355400 | 0.86 | KDM4E (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291624-B2 | CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents | BAYER SCHERING PHARMA AG (DE) | 2007-11-06 | — | — | US | disclosed |
| US-7291624-B2 | CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents | BAYER SCHERING PHARMA AG (DE) | 2007-11-06 | — | — | US | disclosed |