Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14123991 | 0.94 | NPC1 (0.44) | NPC1RAB9AMDM2KMT2AMEN1 | |
| SCHEMBL12568257 | 0.92 | RAB9A (0.43) | NPC1RAB9AMDM2KMT2AMEN1 | |
| SCHEMBL5813924 | 0.92 | NPC1 (0.43) | NPC1RAB9AMDM2KMT2AMEN1 | |
| SCHEMBL29470540 | 0.91 | KMT2A (0.45) | NPC1RAB9AMDM2KMT2AMEN1 | |
| SCHEMBL3367289 | 0.91 | KMT2A (0.45) | NPC1RAB9AMDM2KMT2AMEN1 | |
| SCHEMBL31146900 | 0.91 | KMT2A (0.45) | NPC1RAB9AMDM2KMT2AMEN1 | |
| SCHEMBL1745934 | 0.91 | KMT2A (0.45) | NPC1RAB9AMDM2KMT2AMEN1 | |
| SCHEMBL14416300 | 0.91 | KMT2A (0.42) | NPC1RAB9AMDM2KMT2AMEN1 | |
| SCHEMBL29368397 | 0.91 | KMT2A (0.45) | NPC1RAB9AMDM2KMT2AMEN1 | |
| SCHEMBL1000962 | 0.91 | KMT2A (0.45) | NPC1RAB9AMDM2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867633-A1 | Polyamine analogues as therapeutic and diagnostic agents | MediQuest Therapeutics, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| US-7208528-B1 | Polyamine analogues as therapeutic and diagnostic agents | MEDIQUEST THERAPEUTICS, INC. (US) | 2007-04-24 | — | — | US | disclosed |
| US-7160923-B1 | Polyamine analogues as therapeutic and diagnostic agents | MEDIQUEST THERAPEUTICS, INC. (US) | 2007-01-09 | — | — | US | disclosed |