Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | TOP2A | P11388 | 6/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143726 | 0.89 | TOP2A (0.39) | KCNH2TOP2ATOP2BPIM1GSK3A | |
| SCHEMBL142409 | 0.87 | GSK3B (0.37) | KCNH2TOP2ATOP2BPIM1GSK3A | |
| SCHEMBL143976 | 0.86 | GSK3B (0.36) | KCNH2TOP2ATOP2BPIM1GSK3A | |
| SCHEMBL144443 | 0.86 | GSK3B (0.36) | KCNH2TOP2ATOP2BPIM1GSK3A | |
| SCHEMBL140634 | 0.86 | PIM1 (0.36) | KCNH2TOP2ATOP2BPIM1GSK3A | |
| SCHEMBL3337171 | 0.86 | KCNH2 (0.41) | KCNH2PIM1GSK3AGSK3BPIM3 | |
| SCHEMBL7489369 | 0.86 | STAT3 (0.40) | KCNH2TOP2ATOP2BPIM1GSK3A | |
| SCHEMBL3134076 | 0.84 | KCNH2 (0.38) | KCNH2TOP2ATOP2BPIM1GSK3A | |
| SCHEMBL9308875 | 0.81 | TOP2A (0.61) | TOP2ATOP2B | |
| SCHEMBL29023850 | 0.81 | KDM4E (0.41) | KCNH2TOP2ATOP2BPIM1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| EP-2250171-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | Achaogen, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009137130-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | RECQL, BLVRB, NQO2 | KCNH2 1477/4885TOP2A 125/4885TOP2B 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.