Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.77 |
| ▸ | NPC1 | O15118 | 1/20 | 0.77 |
| ▸ | RAB9A | P51151 | 1/20 | 0.77 |
| ▸ | MAOB | P27338 | 14/20 | 0.72 |
| ▸ | MAOA | P21397 | 5/20 | 0.72 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.58 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.58 |
| ▸ | GCK | P35557 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638863 | 0.86 | NR4A2 (0.77) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL1437471 | 0.85 | MAOB (0.68) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL21483757 | 0.84 | MAOB (0.67) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL2087954 | 0.84 | MAOB (0.71) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL2087098 | 0.84 | MAOB (1.00) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL2087291 | 0.83 | MAOB (0.72) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL10600243 | 0.82 | RAB9A (0.60) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL24686734 | 0.81 | NPC1 (0.53) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL24687054 | 0.81 | NPC1 (0.52) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL5733382 | 0.80 | NR4A2 (0.64) | NR4A2NPC1RAB9AMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933354-B1 | CALCIUM RECEPTOR-ACTIVE COMPOUNDS | KYOWA HAKKO KIRIN CO LTD (JP) | 2011-03-30 | — | — | EP | disclosed |
| US-7816408-B2 | Calcium receptor active compounds | NPS PHARMACEUTICALS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-20090176993-A1 | Calcium receptor active compounds | NPS PHARMACEUTICALS, INC. | 2009-07-09 | — | — | US | disclosed |
| US-6939895-B2 | Calcium receptor-active compounds | NPS PHARMACEUTICALS, INC. (US) | 2005-09-06 | — | — | US | disclosed |
| US-6750255-B2 | SUCH AS (R)-N-(1-(1'-NAPHTHYL)ETHYL)-2-(2',5'-DICHOROPHENYL THIO)ETHYLAMINE; FOR STIMULATION OF SECRETION OF PARATHYROID HORMONE | NPS PHARMACEUTICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-20030176485-A1 | Calcium receptor active compounds | NPS PHARMACEUTICALS, INC. | 2003-09-18 | — | — | US | disclosed |
| US-20030144526-A1 | Calcium receptor-active compounds | NPS PHARMACEUTICALS, INC. | 2003-07-31 | — | — | US | disclosed |
| US-20020107406-A1 | Calcium receptor-active compounds | NPS PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | US | disclosed |
| US-6362231-B1 | MODULATOR OF PARATHYROID HORMONE; OSTEOPOROSIS | NPS PHARMACEUTICALS, INC. | 2002-03-26 | — | — | US | disclosed |
| EP-0933354-A1 | CALCIUM RECEPTOR-ACTIVE COMPOUNDS | KIRIN BEER KABUSHIKI KAISHA (JP) | 1999-08-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144526-A1 | Calcium receptor-active compounds | CASR, CALCR, CNR1 | NR4A2 215/4885NPC1 3949/4885RAB9A 951/4885 |
| US-20090176993-A1 | Calcium receptor active compounds | CASR, CALCR, CACNA1E | NR4A2 40/4885NPC1 4529/4885RAB9A 1201/4885 |
| US-20030176485-A1 | Calcium receptor active compounds | CASR, CNR1, CALCR | NR4A2 275/4885NPC1 3730/4885RAB9A 953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.