Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 14/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 14/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1436724 | 0.93 | PPARG (0.41) | AKR1C3AKR1C2AKR1B10AKR1C4AKR1C1 | |
| SCHEMBL1509419 | 0.91 | AKR1C3 (0.37) | AKR1C3AKR1C2AKR1B10AKR1C4AKR1C1 | |
| SCHEMBL1436505 | 0.89 | PPARG (0.42) | AKR1C3AKR1C2AKR1B10AKR1C4AKR1C1 | |
| SCHEMBL1509213 | 0.87 | PPARG (0.39) | AKR1C3AKR1C2AKR1B10AKR1C4AKR1C1 | |
| SCHEMBL1509421 | 0.86 | ACACB (0.37) | AKR1C3AKR1C2PPARGPPARAPTGES | |
| SCHEMBL1509439 | 0.84 | PTGES (0.41) | PPARGPPARAPTGESALOX5MAPT | |
| SCHEMBL1509456 | 0.84 | MAPK8 (0.38) | PPARGPPARAPTGESALOX5MAPT | |
| SCHEMBL1436359 | 0.83 | PPARG (0.37) | PPARGPPARAPTGESALOX5MAPT | |
| SCHEMBL1436649 | 0.82 | MAPT (0.38) | PPARGPPARAPTGESALOX5MAPT | |
| SCHEMBL1436625 | 0.82 | PTGES (0.36) | PPARGPPARAPTGESALOX5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053892-A1 | Imidazo[4,5-d]Pyridazine Compounds For Treating Viral Infections | LEIVERS MARTIN | 2011-03-03 | — | — | US | disclosed |
| WO-2011026024-A2 | IMIDAZO [4,5-D] PYRIDAZINE COMPOUNDS FOR TREATING VIRAL INFECTIONS | GLAXOSMITHKLINE LLC (US) | 2011-03-03 | — | — | WO | disclosed |
| US-20110052534-A1 | Imidazopyridazine Compounds for Treating Viral Infections | LEIVERS MARTIN | 2011-03-03 | — | — | US | disclosed |
| WO-2011026091-A1 | IMIDAZOPYRIDAZINE COMPOUNDS FOR TREATING VIRAL INFECTIONS | GLAXOSMITHKLINE LLC (US) | 2011-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110052534-A1 | Imidazopyridazine Compounds for Treating Viral Infections | ACE, ACE2, TPMT | AKR1C3 3399/4885AKR1C2 3098/4885AKR1B10 3387/4885 |
| US-20110053892-A1 | Imidazo[4,5-d]Pyridazine Compounds For Treating Viral Infections | MAVS, ZC3HAV1, IL5 | AKR1C3 2525/4885AKR1C2 3000/4885AKR1B10 3270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.