Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | CCR2 | P41597 | 14/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CCR4 | P51679 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308130 | 0.86 | CYP2C9 (0.62) | CYP2C9CYP3A4CCR2CYP2C19CCR4 | |
| SCHEMBL5572258 | 0.83 | CCR2 (0.45) | CYP2C9CCR2 | |
| SCHEMBL306943 | 0.80 | CYP2C9 (0.61) | CYP2C9CYP3A4CCR2CYP2C19CCR4 | |
| SCHEMBL305031 | 0.79 | CYP2C9 (0.60) | CYP2C9CYP3A4CCR2CYP2C19CCR4 | |
| SCHEMBL306174 | 0.78 | CYP2C9 (0.65) | CYP2C9CYP3A4CCR2CYP2C19CCR4 | |
| SCHEMBL10223170 | 0.78 | CYP2C9 (0.62) | CYP2C9CYP3A4CCR2CYP2C19CCR4 | |
| SCHEMBL306041 | 0.78 | CYP2C9 (0.58) | CYP2C9CYP3A4CCR2CYP2C19CCR4 | |
| SCHEMBL10222759 | 0.77 | CYP2C9 (0.61) | CYP2C9CYP3A4CCR2 | |
| SCHEMBL10223305 | 0.77 | CYP2C9 (0.57) | CYP2C9CYP3A4CCR2CYP2C19CCR4 | |
| SCHEMBL10223171 | 0.77 | CYP2C9 (0.63) | CYP2C9CYP3A4CCR2CYP2C19CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838674-B9 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX INC (US) | 2011-11-02 | — | — | EP | disclosed |
| EP-1838674-B1 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX INC (US) | 2011-03-30 | — | — | EP | disclosed |