Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 18/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430954 | 0.87 | CCR2 (0.42) | CCR2CYP2C9HTT | |
| SCHEMBL308218 | 0.83 | CCR2 (0.49) | CCR2CYP2C9 | |
| SCHEMBL306504 | 0.83 | CCR2 (0.60) | CCR2CYP2C9 | |
| SCHEMBL1436620 | 0.83 | CYP2C9 (0.48) | CCR2CYP2C9 | |
| SCHEMBL1762387 | 0.81 | CCR2 (0.51) | CCR2CYP2C9 | |
| SCHEMBL1762426 | 0.79 | CCR2 (0.55) | CCR2CYP2C9 | |
| SCHEMBL1762410 | 0.76 | CCR2 (0.51) | CCR2CYP2C9 | |
| SCHEMBL15259953 | 0.75 | CCR2 (0.42) | CCR2CYP2C9 | |
| SCHEMBL1762391 | 0.75 | CCR2 (0.49) | CCR2CYP2C9 | |
| SCHEMBL306008 | 0.75 | CCR2 (0.58) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838674-A2 | HETEROARYL SULFONAMIDES AND CCR2 | ChemoCentryx Inc (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006076644-A2 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX, INC. (US) | 2006-07-20 | — | — | WO | disclosed |