Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 5/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14391887 | 1.00 | SLC18A3 (0.54) | SLC18A3SIGMAR1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5578861 | 1.00 | SLC18A3 (0.54) | SLC18A3SIGMAR1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5578858 | 1.00 | SLC18A3 (0.54) | SLC18A3SIGMAR1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5578856 | 1.00 | SLC18A3 (0.54) | SLC18A3SIGMAR1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5578832 | 0.85 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2GAAL3MBTL1HSP90AA1 | |
| SCHEMBL5578674 | 0.72 | ALDH1A1 (0.43) | SIGMAR1ALDH1A1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL14366294 | 0.69 | SLC18A3 (0.39) | SLC18A3ALDH1A1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL5578438 | 0.69 | SLC18A3 (0.39) | SLC18A3ALDH1A1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL5578440 | 0.69 | SLC18A3 (0.39) | SLC18A3ALDH1A1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL14391914 | 0.69 | SLC18A3 (0.39) | SLC18A3ALDH1A1SMN1; SMN2GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | REN, AVPR2, RECQL | SLC18A3 2869/4885SIGMAR1 444/4885ALDH1A1 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.