Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.69 |
| ▸ | RAB9A | P51151 | 8/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.63 |
| ▸ | RELA | Q04206 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8267173 | 0.87 | NPC1 (0.90) | NPC1RAB9AALDH1A1TP53GLA | |
| SCHEMBL8267406 | 0.85 | MEN1 (0.72) | NPC1RAB9AALDH1A1TP53GLA | |
| SCHEMBL25235561 | 0.83 | MAPT (0.67) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL25206621 | 0.83 | ALDH1A1 (0.59) | NPC1RAB9AALDH1A1TP53GLA | |
| SCHEMBL10192186 | 0.82 | NPC1 (1.00) | NPC1RAB9AALDH1A1TP53GLA | |
| SCHEMBL8267152 | 0.81 | NPC1 (0.79) | NPC1RAB9AALDH1A1TP53GLA | |
| SCHEMBL13321363 | 0.81 | RAB9A (0.79) | NPC1RAB9AALDH1A1TP53GLA | |
| SCHEMBL8266861 | 0.80 | NPC1 (0.77) | NPC1RAB9AALDH1A1TP53GLA | |
| SCHEMBL8266868 | 0.79 | RAB9A (0.77) | NPC1RAB9AALDH1A1TP53GLA | |
| SCHEMBL1394901 | 0.78 | NPC1 (0.75) | NPC1RAB9AALDH1A1TP53GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291743-B2 | Isoxazole derivatives and methods of treating nitric oxide mediated diseases | GENEBLUE CORPORATION (US) | 2007-11-06 | — | — | US | disclosed |
| US-7291743-B2 | Isoxazole derivatives and methods of treating nitric oxide mediated diseases | GENEBLUE CORPORATION (US) | 2007-11-06 | — | — | US | disclosed |