Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 8/20 | 0.54 |
| ▸ | HRH1 | P35367 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14367171 | 1.00 | OPRD1 (0.54) | OPRD1HRH1LMNACYP3A4HIF1A | |
| SCHEMBL1138084 | 0.90 | NPC1 (0.60) | OPRD1HRH1LMNACYP3A4HIF1A | |
| SCHEMBL1138082 | 0.90 | NPC1 (0.60) | OPRD1HRH1LMNACYP3A4HIF1A | |
| Hydrochloric Acid SCHEMBL1138342 | 0.89 | HRH1 (0.58) | OPRD1HRH1LMNACYP3A4HIF1A | |
| Hydrochloric Acid SCHEMBL1138343 | 0.89 | HRH1 (0.58) | OPRD1HRH1LMNACYP3A4HIF1A | |
| SCHEMBL6554369 | 0.85 | OPRD1 (0.56) | OPRD1HRH1LMNACYP3A4HIF1A | |
| SCHEMBL5623789 | 0.84 | HRH1 (0.69) | OPRD1HRH1LMNACYP3A4HIF1A | |
| SCHEMBL1138127 | 0.84 | HRH1 (0.69) | OPRD1HRH1LMNACYP3A4HIF1A | |
| SCHEMBL1138165 | 0.84 | LMNA (0.60) | OPRD1HRH1LMNACYP3A4HIF1A | |
| SCHEMBL1138130 | 0.84 | HRH1 (0.69) | OPRD1HRH1LMNACYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297697-B2 | with alkenyl moiety substituted at the 1-position of the piperazine unit; useful in the treatment of histamine mediated diseases | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2007-11-20 | — | — | US | disclosed |