Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 15/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 15/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 15/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 15/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 15/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 15/20 | 0.41 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345083 | 0.85 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3342859 | 0.78 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3340914 | 0.78 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL14260855 | 0.78 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL14367226 | 0.74 | MEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3345084 | 0.73 | ALDH1A1 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5227301 | 0.73 | KDM1A (0.46) | ALDH1A1 | |
| SCHEMBL14260860 | 0.72 | ALDH1A1 (0.53) | ALDH1A1KDM4ETP53POLB | |
| SCHEMBL4988269 | 0.72 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3343553 | 0.71 | PSEN1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |