Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 2/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | MC5R | P33032 | 1/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | MC1R | Q01726 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227313 | 0.84 | ALDH1A1 (0.36) | ALDH1A1HSD17B2MEN1KMT2ARIPK1 | |
| SCHEMBL3345083 | 0.79 | PSEN1 (0.49) | — | |
| SCHEMBL3343463 | 0.77 | ALDH1A1 (0.40) | ALDH1A1HSD17B2MEN1KMT2A | |
| SCHEMBL14260860 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8338572 | 0.76 | KDM4E (0.40) | ALDH1A1HSD17B2 | |
| SCHEMBL3344892 | 0.76 | KDM4E (0.40) | ALDH1A1HSD17B2 | |
| SCHEMBL14260858 | 0.76 | KDM4E (0.40) | ALDH1A1HSD17B2 | |
| SCHEMBL4117171 | 0.76 | TP53 (0.39) | KDM1AALDH1A1HSD17B2 | |
| SCHEMBL14260868 | 0.76 | TP53 (0.39) | KDM1AALDH1A1HSD17B2 | |
| SCHEMBL14260855 | 0.75 | ALDH1A1 (0.39) | ALDH1A1HSD17B2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845089-A1 | Novel lactams and uses thereof | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |