Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14260874 | 1.00 | MAPT (0.42) | MAPTL3MBTL1ALDH1A1GAAHTT | |
| SCHEMBL8340434 | 0.88 | MAPT (0.43) | MAPTL3MBTL1ALDH1A1GAAHTT | |
| SCHEMBL14260875 | 0.88 | MAPT (0.43) | MAPTL3MBTL1ALDH1A1GAAHTT | |
| SCHEMBL14260873 | 0.87 | MAPT (0.43) | MAPTL3MBTL1ALDH1A1GAAHTT | |
| SCHEMBL8340048 | 0.87 | MAPT (0.43) | MAPTL3MBTL1ALDH1A1GAAHTT | |
| SCHEMBL27771907 | 0.87 | MAPT (0.43) | MAPTL3MBTL1ALDH1A1GAAHTT | |
| SCHEMBL8340243 | 0.86 | MAPT (0.40) | MAPTL3MBTL1ALDH1A1GAAHTT | |
| SCHEMBL14260871 | 0.84 | ALDH1A1 (0.39) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL14393399 | 0.82 | MAPT (0.40) | MAPTL3MBTL1ALDH1A1GAAHTT | |
| SCHEMBL14260872 | 0.82 | MAPT (0.40) | MAPTL3MBTL1ALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |