Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14393401 | 0.86 | CTSK (0.38) | MAPTCTSSCTSKSCN9A | |
| SCHEMBL14367241 | 0.86 | MAPT (0.42) | MAPTALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL14260874 | 0.86 | MAPT (0.42) | MAPTALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL14260875 | 0.82 | MAPT (0.43) | MAPTALDH1A1HTTFBP1L3MBTL1 | |
| SCHEMBL8340434 | 0.82 | MAPT (0.43) | MAPTALDH1A1HTTFBP1L3MBTL1 | |
| SCHEMBL8340048 | 0.81 | MAPT (0.43) | MAPTALDH1A1HTTFBP1L3MBTL1 | |
| SCHEMBL14260873 | 0.81 | MAPT (0.43) | MAPTALDH1A1HTTFBP1L3MBTL1 | |
| SCHEMBL27771907 | 0.81 | MAPT (0.43) | MAPTALDH1A1HTTFBP1L3MBTL1 | |
| SCHEMBL4121000 | 0.80 | ALDH1A1 (0.43) | MAPTALDH1A1HTTCTSSCTSK | |
| SCHEMBL4121004 | 0.80 | ALDH1A1 (0.43) | MAPTALDH1A1HTTCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |
| WO-2004031154-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |