Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.59 |
| ▸ | HPGD | P15428 | 10/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | STAT3 | P40763 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566933 | 0.84 | KDM4E (0.69) | KDM4EHPGDALDH1A1MAPTLMNA | |
| SCHEMBL8931341 | 0.80 | KDM4E (0.60) | KDM4EHPGDALDH1A1MAPTLMNA | |
| SCHEMBL15759949 | 0.79 | TDP1 (0.45) | KDM4EHPGDALDH1A1MAPTLMNA | |
| SCHEMBL14345186 | 0.79 | APOBEC3G (0.50) | KDM4EHPGDALDH1A1MAPTLMNA | |
| SCHEMBL7694437 | 0.74 | HPGD (0.71) | KDM4EHPGDALDH1A1LMNATDP1 | |
| SCHEMBL31295490 | 0.73 | KDM4E (0.57) | KDM4EHPGDALDH1A1MAPTLMNA | |
| SCHEMBL31295361 | 0.73 | KDM4E (0.56) | KDM4EHPGDALDH1A1MAPTLMNA | |
| SCHEMBL8931366 | 0.72 | ALDH1A1 (0.47) | KDM4EHPGDALDH1A1MAPTLMNA | |
| SCHEMBL7687616 | 0.72 | HPGD (0.87) | KDM4EHPGDALDH1A1LMNAPKM | |
| SCHEMBL13983500 | 0.70 | HSP90AA1 (0.47) | KDM4EHPGDALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139955-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-12-06 | — | — | WO | disclosed |