Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.77 |
| ▸ | HTR3A | P46098 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | VDR | P11473 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2959889 | 0.88 | TOP2A (0.61) | TOP2AHTR3AKCNH2CYP3A4VDR | |
| SCHEMBL11979724 | 0.87 | TOP2A (1.00) | TOP2AHTR3AKCNH2CYP3A4VDR | |
| SCHEMBL17929359 | 0.87 | TOP2A (0.78) | TOP2AHTR3AKCNH2CYP3A4VDR | |
| SCHEMBL29354263 | 0.87 | TOP2A (1.00) | TOP2AHTR3AKCNH2CYP3A4VDR | |
| SCHEMBL17929348 | 0.87 | TOP2A (1.00) | TOP2AHTR3AKCNH2CYP3A4VDR | |
| SCHEMBL17931469 | 0.86 | TOP2A (0.77) | TOP2AHTR3AKCNH2CYP3A4VDR | |
| SCHEMBL17929349 | 0.86 | TOP2A (0.77) | TOP2AHTR3AKCNH2CYP3A4VDR | |
| SCHEMBL17929362 | 0.86 | TOP2A (0.77) | TOP2AHTR3AKCNH2CYP3A4VDR | |
| SCHEMBL17929363 | 0.85 | TOP2A (0.76) | TOP2AHTR3AKCNH2CYP3A4VDR | |
| SCHEMBL5619653 | 0.84 | TOP2A (0.95) | TOP2AHTR3AKCNH2CYP3A4VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160207909-A1 | Synthesis Method of Anti-Cancer Drug UK-1 and Derivatives Thereof | HUANG YUNG-TZUNG (TW) | 2016-07-21 | — | — | US | disclosed |
| US-7294643-B2 | UK-1 analogues: methods of preparation and use | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-11-13 | — | — | US | disclosed |
| US-7294643-B2 | UK-1 analogues: methods of preparation and use | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207909-A1 | Synthesis Method of Anti-Cancer Drug UK-1 and Derivatives Thereof | ALDH7A1, ADH1A, ALDH1A1 | TOP2A 300/4885HTR3A 377/4885KCNH2 4016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.