Xanthohumol

Xanthohumol

SCHEMBL143683

COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)/C=C/c1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 1.00
TTR P02766 1/20 1.00
ALOX5 P09917 1/20 1.00
ABCB1 P08183 13/20 0.73
MAPT P10636 2/20 0.66
MEN1 O00255 1/20 0.66
LMNA P02545 1/20 0.66
MAOB P27338 1/20 0.66
KMT2A Q03164 1/20 0.66
MGAM O43451 1/20 0.64
SENP8 Q96LD8 1/20 0.64
SENP7 Q9BQF6 1/20 0.64
SENP6 Q9GZR1 1/20 0.64
PTPN1 P18031 1/20 0.61
DHODH Q02127 1/20 0.61
NFKB1 P19838 1/20 0.59
DPP4 P27487 1/20 0.59
NFKB2 Q00653 1/20 0.59
RELA Q04206 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Xanthohumol SCHEMBL738122 1.00 PDPK1 (1.00) PDPK1TTRALOX5ABCB1MAPT
Xanthohumol SCHEMBL30169731 1.00 PDPK1 (1.00) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL26539037 0.97 PDPK1 (0.93) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL30630210 0.97 PDPK1 (0.93) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL16450254 0.92 PDPK1 (0.86) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL144848 0.92 ABCB1 (0.85) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL16174029 0.91 ABCB1 (0.86) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL26538024 0.91 PDPK1 (0.84) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL31415696 0.91 PDPK1 (0.84) PDPK1TTRALOX5ABCB1MAPT
Xanthogalenol SCHEMBL30259154 0.91 PDPK1 (0.84) PDPK1TTRALOX5ABCB1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3726 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117551068-B Isofluoside alcohol amine copolymer, preparation method and antibacterial application thereof University of South China (CN) 2026-05-26 CN claimed
US-12636261-B2 Treatment of inflammation initiated by the spinal cord injury, the traumatic brain injury, stroke, in inhibition of cerebral and spinal cord edema and of inflammation in neurodegenerative, immune mediated and infectious diseases of the central nervous system Kwiecien, Jacek M. (CA) 2026-05-26 US claimed
CN-122056865-A Application of xanthotoxin in preparation of medicines for treating liver cancer 蕲春县人民医院 2026-05-19 CN claimed
CN-122056926-A Probiotic composition containing melatonin and application of composition in sleep 南京北极光生物科技有限公司 2026-05-19 CN claimed
CN-117838676-B Application of xanthohumol in preparation of medicine for resisting aeromonas hydrophila infection of aquaculture animals 中国水产科学研究院长江水产研究所 2026-05-15 CN claimed
EP-4739298-A1 ACTIVATORS OF THE XC- SYSTEM AND/OR GPX-4 FOR TREATING CONDITIONS ASSOCIATED WITH CONE PHOTORECEPTOR DEGENERATION SORBONNE UNIVERSITE (FR) 2026-05-13 EP claimed
CN-122017224-A Method for screening antibacterial compounds by high-flux targeted phytophthora elicitin based on DHE fluorescence intensity and application 南京农业大学三亚研究院 2026-05-12 CN claimed
EP-4698155-A1 OIL FREE LIPID NANOPARTICLES FOR STABILIZING HYDROPHOBIC AGENTS AND METHODS OF USE THEREOF Corenhanced Technologies LLC (US) 2026-02-25 EP claimed
US-20260048095-A1 Treatment of Neuroinflammation KWIECIEN JACEK (CA) 2026-02-19 US claimed
EP-4679087-A1 BIOMARKER AND USE THEREOF MEIJI CO., LTD (JP) 2026-01-14 EP claimed
WO-2003000185-A2 COMPLEX MIXTURES EXHIBITING SELECTIVE INHIBITION OF CYCLOOXYGENASE-2 METAPROTEOMICS, LLC (US) 2003-01-03 WO claimed
WO-2002085393-A1 HOP EXTRACTS AND USE THEREOF IN THE PRODUCTION OF A MEDICAMENT HAVING ESTROGENIC PROPERTIES BERKEM (FR) 2002-10-31 WO claimed
WO-2002080708-A2 A SMOKER'S REQUISITE ENSLIN GEORGE FREDERICK (ZA) 2002-10-17 WO claimed
US-6423317-B1 KILLING PROTOZOA WITH HOP PLANT EXTRACTS S.S. STEINER, INC. 2002-07-23 US claimed
US-6391346-B1 COMPOSITION COMPRISING POST-SUPERCRITICAL CARBON DIOXIDE HYDROALCOHOLIC EXTRACT OF GINGER; SUPERCRITICAL CARBON DIOXIDE EXTRACTS OF HOPS, CHAMOMILE, GINGER, VALERIAN, MELISSA; HYDROALCOHOLIC EXTRACTS OF HOLY BASIL, TURMERIC, SCUTELLARIA NEW CHAPTER, INC. 2002-05-21 US claimed
US-6352726-B1 BUBBLING CARBON DIOXIDE THROUGH HOP PLANT EXTRACT CONTAINING ALPHA AND/OR BETA RESINS AND XANTHOHUMOL; CARBONATION S. S. STEINER, INC. 2002-03-05 US claimed
WO-2001003687-A2 METHOD AND COMPOSITIONS FOR INHIBITING BIOSYNTHESIS OR BIOACTIVITY OF ENDOGENOUS STEROID SEX HORMONES IN HUMANS CEDARS-SINAI MEDICAL CENTER (US) 2001-01-18 WO claimed
EP-0679393-B1 Pharmaceutical composition for treating osteoporosis containing xanthohumol HOECHST JAPAN (JP) 1998-01-14 EP claimed
US-5679716-A ADMINISTERING XANTHOHUMOL HOECHST JAPAN LIMITED (JP) 1997-10-21 US claimed
EP-0679393-A2 Pharmaceutical composition for treating osteoporosis containing xanthohumol HOECHST JAPAN LIMITED (JP) 1995-11-02 EP claimed