Xanthohumol

Xanthohumol

SCHEMBL30169731

COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)/C=C/c1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 1.00
TTR P02766 1/20 1.00
ALOX5 P09917 1/20 1.00
ABCB1 P08183 13/20 0.73
MAPT P10636 2/20 0.66
MEN1 O00255 1/20 0.66
LMNA P02545 1/20 0.66
MAOB P27338 1/20 0.66
KMT2A Q03164 1/20 0.66
MGAM O43451 1/20 0.64
SENP8 Q96LD8 1/20 0.64
SENP7 Q9BQF6 1/20 0.64
SENP6 Q9GZR1 1/20 0.64
PTPN1 P18031 1/20 0.61
DHODH Q02127 1/20 0.61
NFKB1 P19838 1/20 0.59
DPP4 P27487 1/20 0.59
NFKB2 Q00653 1/20 0.59
RELA Q04206 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Xanthohumol SCHEMBL738122 1.00 PDPK1 (1.00) PDPK1TTRALOX5ABCB1MAPT
Xanthohumol SCHEMBL143683 1.00 PDPK1 (1.00) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL26539037 0.97 PDPK1 (0.93) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL30630210 0.97 PDPK1 (0.93) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL16450254 0.92 PDPK1 (0.86) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL144848 0.92 ABCB1 (0.85) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL16174029 0.91 ABCB1 (0.86) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL26538024 0.91 PDPK1 (0.84) PDPK1TTRALOX5ABCB1MAPT
SCHEMBL31415696 0.91 PDPK1 (0.84) PDPK1TTRALOX5ABCB1MAPT
Xanthogalenol SCHEMBL30259154 0.91 PDPK1 (0.84) PDPK1TTRALOX5ABCB1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116660543-A Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof 中国人民解放军陆军军医大学第一附属医院 2023-08-29 CN claimed
EP-4499054-A1 ANTIVIRAL COMPOSITION COMPRISING CHITOSAN AND XANTHOHUMOLONE Health Plus (FR) 2025-02-05 EP disclosed
US-20250009709-A1 PRENYLATED CHALCONE AND FLAVONOID COMPOSITIONS FOR USE IN TREATING CANCER INNOX Corp. (US) 2025-01-09 US disclosed
EP-4366723-A1 PRENYLATED CHALCONE AND FLAVONOID COMPOSITIONS FOR USE IN TREATING CANCER Innox Corp. (US) 2024-05-15 EP disclosed
WO-2023186804-A1 ANTIVIRAL COMPOSITION COMPRISING CHITOSAN AND XANTHOHUMOLONE HEALTH PLUS (FR) 2023-10-05 WO disclosed
WO-2023283418-A1 PRENYLATED CHALCONE AND FLAVONOID COMPOSITIONS FOR USE IN TREATING CANCER INNOX Corp. (US) 2023-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250009709-A1 PRENYLATED CHALCONE AND FLAVONOID COMPOSITIONS FOR USE IN TREATING CANCER CYP46A1, NR1H3, NR1H2 PDPK1 15/4885TTR 2934/4885ALOX5 1797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.