Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CCR4 | P51679 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | CCR9 | P51686 | 8/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304908 | 0.79 | CCR9 (0.55) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL12161518 | 0.77 | FFAR4 (0.51) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL10222601 | 0.76 | FFAR4 (0.50) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL12595050 | 0.74 | CCR9 (0.44) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL10223736 | 0.74 | CCR2 (0.58) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL10223655 | 0.74 | CCR9 (0.57) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL14458036 | 0.72 | NAMPT (0.49) | CCR2ALDH1A1POLBCCR9LMNA | |
| SCHEMBL343122 | 0.72 | CCR9 (0.75) | CCR9LMNAHTT | |
| SCHEMBL10222598 | 0.72 | CCR9 (0.49) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL10223642 | 0.72 | FFAR4 (0.43) | CCR2CYP3A4CYP2C9CYP2C19CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838674-B9 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX INC (US) | 2011-11-02 | — | — | EP | disclosed |
| EP-1838674-B1 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX INC (US) | 2011-03-30 | — | — | EP | disclosed |