Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 4/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | BIRC3 | Q13489 | 1/20 | 0.43 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12914622 | 1.00 | HPGD (0.47) | HPGDSMN1; SMN2ALDH1A1L3MBTL1FAAH | |
| SCHEMBL12450938 | 0.87 | FAAH (0.46) | HPGDSMN1; SMN2ALDH1A1L3MBTL1FAAH | |
| SCHEMBL8763113 | 0.84 | XIAP (0.43) | HPGDSMN1; SMN2ALDH1A1L3MBTL1FAAH | |
| SCHEMBL8763121 | 0.84 | HPGD (0.42) | HPGDSMN1; SMN2ALDH1A1FAAHNPC1 | |
| SCHEMBL950189 | 0.82 | CASP1 (0.52) | HPGDSMN1; SMN2XIAPBIRC3BIRC2 | |
| SCHEMBL14370033 | 0.82 | CASP1 (0.52) | HPGDSMN1; SMN2XIAPBIRC3BIRC2 | |
| SCHEMBL12946457 | 0.82 | CASP1 (0.42) | HPGDSMN1; SMN2ALDH1A1FAAHNPC1 | |
| SCHEMBL950190 | 0.82 | CASP1 (0.52) | HPGDSMN1; SMN2XIAPBIRC3BIRC2 | |
| SCHEMBL12914620 | 0.82 | CASP1 (0.52) | HPGDSMN1; SMN2XIAPBIRC3BIRC2 | |
| SCHEMBL12450522 | 0.81 | CASP1 (0.46) | HPGDSMN1; SMN2FAAHNPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288624-B2 | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-30 | — | — | US | disclosed |