Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6904768 | 0.74 | HTR2A (0.47) | PRCP | |
| SCHEMBL17414488 | 0.73 | LMNA (0.39) | POLB | |
| SCHEMBL123507 | 0.69 | KMT2A (0.44) | ALDH1A1 | |
| SCHEMBL24119330 | 0.69 | CYP2A6 (0.41) | SRD5A1 | |
| SCHEMBL7772712 | 0.69 | PRCP (0.42) | PRCPSMN1; SMN2NPSR1TAAR1 | |
| SCHEMBL16230661 | 0.68 | ANPEP (0.53) | SMN1; SMN2 | |
| SCHEMBL24119518 | 0.68 | CYP1A2 (0.52) | SMN1; SMN2MTNR1B | |
| SCHEMBL10204121 | 0.68 | PRCP (0.42) | PRCPDRD1CHRNA7TAAR1 | |
| SCHEMBL2608413 | 0.68 | ALDH1A1 (0.48) | DRD1KDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL29857924 | 0.68 | ALDH1A1 (0.48) | DRD1KDM4EALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276495-B2 | Substituted lactams as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-10-02 | — | — | US | disclosed |