Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546627 | 0.83 | HTT (0.77) | HTTALDH1A1NPSR1HRH3KDM4E | |
| SCHEMBL3823611 | 0.82 | HTT (0.70) | HTTALDH1A1NPSR1HRH3KDM4E | |
| SCHEMBL3585672 | 0.81 | HTT (0.74) | HTTALDH1A1NPSR1HRH3KDM4E | |
| SCHEMBL1243301 | 0.80 | HTT (1.00) | HTTALDH1A1NPSR1HRH3KDM4E | |
| SCHEMBL25062524 | 0.79 | HTT (0.58) | HTTALDH1A1NPSR1KDM4EGAA | |
| Hydrochloric Acid SCHEMBL3500894 | 0.79 | HTT (0.97) | HTTALDH1A1NPSR1HRH3KDM4E | |
| SCHEMBL21044234 | 0.79 | HTT (0.70) | HTTALDH1A1NPSR1HRH3KDM4E | |
| SCHEMBL14375213 | 0.78 | ACHE (0.49) | ALDH1A1NPSR1HRH3ACHEPOLB | |
| SCHEMBL3824247 | 0.78 | HTT (0.68) | HTTALDH1A1NPSR1HRH3KDM4E | |
| SCHEMBL25062762 | 0.77 | HTT (0.52) | HTTALDH1A1HRH3KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070244133-A1 | Thienopyrimidines and Thiazolopyrimidines for Use in Medicine | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244133-A1 | Thienopyrimidines and Thiazolopyrimidines for Use in Medicine | CXCR4, CXCR1, CXCR3 | HTT 4578/4885ALDH1A1 683/4885NPSR1 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.