Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.63 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | YES1 | P07947 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15877629 | 1.00 | NPC1 (0.65) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL14376560 | 0.85 | NPC1 (0.67) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL14335878 | 0.82 | KMT2A (0.69) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL14335879 | 0.82 | KMT2A (0.69) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL15879182 | 0.82 | NPC1 (0.69) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL14375860 | 0.82 | NPC1 (0.69) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL15896534 | 0.81 | SRC (0.46) | PDPK1SRCRETFLT3ALK | |
| SCHEMBL24967118 | 0.81 | NPC1 (0.55) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL30155085 | 0.81 | NPC1 (0.55) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL30155038 | 0.81 | NPC1 (0.55) | NPC1MAPTKMT2AGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140205537-A1 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2014-07-24 | — | — | US | claimed |
| US-20140205537-A1 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2014-07-24 | — | — | US | disclosed |
| US-20140205537-A1 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2014-07-24 | — | — | US | disclosed |
| WO-2012178015-A2 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140205537-A1 | LRRK2 INHIBITORS | LRRK2, PARK7, MAP2 | NPC1 875/4885MAPT 67/4885KMT2A 1348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.