Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.52 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30155085 | 1.00 | NPC1 (0.55) | NPC1GAAMAPTKMT2ATDP1 | |
| SCHEMBL30155038 | 1.00 | NPC1 (0.55) | NPC1GAAMAPTKMT2ATDP1 | |
| SCHEMBL17674505 | 0.84 | PDPK1 (0.74) | NPC1MAPTPDPK1AURKAAURKB | |
| SCHEMBL17679344 | 0.84 | PDPK1 (0.74) | NPC1MAPTPDPK1AURKAAURKB | |
| SCHEMBL23369116 | 0.84 | PDPK1 (0.74) | NPC1MAPTPDPK1AURKAAURKB | |
| SCHEMBL24967154 | 0.84 | TLK2 (0.55) | PDPK1MAP4K1PAK4PTPRCBRD4 | |
| SCHEMBL30155027 | 0.84 | TLK2 (0.55) | PDPK1MAP4K1PAK4PTPRCBRD4 | |
| SCHEMBL24967119 | 0.81 | NPC1 (0.56) | NPC1GAAMAPTKMT2ATDP1 | |
| SCHEMBL15877629 | 0.81 | NPC1 (0.65) | NPC1GAAMAPTKMT2ATDP1 | |
| SCHEMBL14375854 | 0.81 | NPC1 (0.65) | NPC1GAAMAPTKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001942-A1 | 14-3-3 PROTEIN MODULATORS AS ANTITUMOR AGENTS | RAPPOSELLI SIMONA (IT) | 2023-01-26 | — | — | WO | disclosed |