Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14376003 | 0.83 | TP53 (0.42) | TP53MAPTGAARAD52HTT | |
| SCHEMBL14853114 | 0.81 | OPRK1 (0.39) | — | |
| SCHEMBL14349219 | 0.81 | TP53 (0.41) | TP53MAPTGAARAD52HTT | |
| SCHEMBL19446958 | 0.81 | HRH4 (0.48) | TP53ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL12991619 | 0.80 | CNR2 (0.50) | TP53MAPTHTTALDH1A1MEN1 | |
| SCHEMBL3436557 | 0.79 | MEN1 (0.46) | TP53MAPTGAAALDH1A1MEN1 | |
| SCHEMBL16945095 | 0.79 | CNR2 (0.53) | TP53MAPTHTTALDH1A1NPSR1 | |
| SCHEMBL14349474 | 0.78 | TP53 (0.39) | TP53MAPTGAARAD52HTT | |
| SCHEMBL2366129 | 0.77 | TAAR1 (0.47) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2366927 | 0.76 | TAAR1 (0.46) | ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |