Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349474 | 0.86 | TP53 (0.39) | TP53MAPTALDH1A1HTTGAA | |
| SCHEMBL12125945 | 0.83 | KDM2B (0.43) | MAPTALDH1A1NPSR1LMNAMEN1 | |
| SCHEMBL14376077 | 0.83 | TP53 (0.44) | TP53MAPTALDH1A1HTTGAA | |
| SCHEMBL13678371 | 0.82 | MEN1 (0.41) | TP53MAPTALDH1A1HTTLMNA | |
| SCHEMBL19001046 | 0.81 | LMNA (0.41) | MAPTALDH1A1HTTLMNAMEN1 | |
| SCHEMBL10203343 | 0.80 | MEN1 (0.38) | ALDH1A1HTTLMNAMEN1KMT2A | |
| SCHEMBL13657963 | 0.78 | ALDH1A1 (0.42) | MAPTALDH1A1GAALMNAMEN1 | |
| SCHEMBL14349219 | 0.78 | TP53 (0.41) | TP53MAPTALDH1A1HTTGAA | |
| SCHEMBL14349615 | 0.74 | KDM4E (0.52) | MAPTALDH1A1GAALMNAKMT2A | |
| SCHEMBL10203156 | 0.72 | OPRK1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |