Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | PAK4 | O96013 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.47 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14376556 | 0.86 | NPC1 (0.71) | KMT2ANPC1MAPTPOLBRAB9A | |
| SCHEMBL14335878 | 0.84 | KMT2A (0.69) | KMT2ANPC1MAPTPOLBRAB9A | |
| SCHEMBL14335879 | 0.84 | KMT2A (0.69) | KMT2ANPC1MAPTPOLBRAB9A | |
| SCHEMBL15879045 | 0.84 | NPC1 (0.68) | KMT2ANPC1MAPTPOLBRAB9A | |
| SCHEMBL14376571 | 0.84 | MAPT (0.68) | KMT2ANPC1MAPTPOLBRAB9A | |
| SCHEMBL14376466 | 0.84 | NPC1 (0.68) | KMT2ANPC1MAPTPOLBRAB9A | |
| SCHEMBL14376560 | 0.83 | NPC1 (0.67) | KMT2ANPC1MAPTPOLBRAB9A | |
| SCHEMBL14376577 | 0.83 | NPC1 (0.63) | KMT2ANPC1MAPTPOLBRAB9A | |
| SCHEMBL14376575 | 0.82 | LRRK2 (0.77) | KMT2ANPC1MAPTPOLBRAB9A | |
| SCHEMBL14376376 | 0.81 | KMT2A (0.53) | KMT2ANPC1MAPTPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140205537-A1 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2014-07-24 | — | — | US | disclosed |
| WO-2012178015-A2 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140205537-A1 | LRRK2 INHIBITORS | LRRK2, PARK7, MAP2 | KMT2A 1348/4885NPC1 875/4885MAPT 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.