Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | PAK4 | O96013 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14376384 | 0.86 | KMT2A (0.71) | NPC1MAPTKMT2APOLBRAB9A | |
| SCHEMBL14375860 | 0.84 | NPC1 (0.69) | NPC1MAPTKMT2APAK4PDGFRB | |
| SCHEMBL15879182 | 0.84 | NPC1 (0.69) | NPC1MAPTKMT2APAK4PDGFRB | |
| SCHEMBL15879045 | 0.84 | NPC1 (0.68) | NPC1MAPTKMT2APOLBRAB9A | |
| SCHEMBL14376466 | 0.84 | NPC1 (0.68) | NPC1MAPTKMT2APOLBRAB9A | |
| SCHEMBL14376571 | 0.84 | MAPT (0.68) | NPC1MAPTKMT2APOLBRAB9A | |
| SCHEMBL14376560 | 0.83 | NPC1 (0.67) | NPC1MAPTKMT2APOLBRAB9A | |
| SCHEMBL14376575 | 0.82 | LRRK2 (0.77) | NPC1MAPTKMT2APOLBRAB9A | |
| SCHEMBL14376577 | 0.81 | NPC1 (0.63) | NPC1MAPTKMT2APOLBRAB9A | |
| SCHEMBL14375845 | 0.75 | RET (0.62) | PDGFRBRETLRRK2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140205537-A1 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2014-07-24 | — | — | US | disclosed |
| WO-2012178015-A2 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140205537-A1 | LRRK2 INHIBITORS | LRRK2, PARK7, MAP2 | NPC1 875/4885MAPT 67/4885KMT2A 1348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.