Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.61 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2833452 | 0.86 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL1649282 | 0.86 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL9853831 | 0.84 | HSD17B10 (0.58) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL18964182 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL9755165 | 0.82 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL11233617 | 0.81 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL11217868 | 0.81 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL12208227 | 0.80 | CA12 (0.61) | CA1CA2PTGS2CA12CA7 | |
| SCHEMBL8428483 | 0.80 | CA1 (0.58) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL658651 | 0.80 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585541-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING INSULIN AND LEGENDS OF INSULIN HEXAMER | NOVO NORDISK AS (DK) | 2007-11-14 | — | — | EP | disclosed |
| EP-1429763-B1 | NOVEL LIGANDS FOR THE HisB10 Zn2+ SITES OF THE R-STATE INSULIN HEXAMER | NOVO NORDISK AS (DK) | 2007-05-30 | — | — | EP | disclosed |