Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP7 | P09237 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP12 | P39900 | 3/20 | 0.42 |
| ▸ | MMP14 | P50281 | 3/20 | 0.42 |
| ▸ | MMP15 | P51511 | 3/20 | 0.42 |
| ▸ | MMP16 | P51512 | 3/20 | 0.42 |
| ▸ | MMP26 | Q9NRE1 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14404661 | 0.89 | CA1 (0.37) | ESR1ESR2 | |
| SCHEMBL5108646 | 0.88 | ESR1 (0.49) | ESR1ESR2GRIN1GRIN2BMAPT | |
| SCHEMBL14382000 | 0.85 | MMP1 (0.41) | ESR1ESR2GRIN1GRIN2BMMP1 | |
| SCHEMBL5109199 | 0.82 | ESR1 (0.63) | ESR1ESR2GRIN1GRIN2BHRH3 | |
| SCHEMBL5640907 | 0.81 | ESR1 (0.53) | ESR1ESR2GRIN1GRIN2BMMP1 | |
| SCHEMBL5102975 | 0.81 | ESR1 (0.53) | ESR1ESR2GRIN1GRIN2BHRH3 | |
| SCHEMBL5108778 | 0.81 | ESR1 (0.53) | ESR1ESR2GRIN1GRIN2BHRH3 | |
| SCHEMBL5102614 | 0.81 | GRIN1 (0.53) | ESR1ESR2GRIN1GRIN2BMMP1 | |
| SCHEMBL5641228 | 0.80 | GRIN1 (0.60) | ESR1ESR2GRIN1GRIN2BHRH3 | |
| SCHEMBL5113517 | 0.79 | ESR1 (0.49) | ESR1ESR2MMP1MMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279489-B2 | Compounds and methods for modulation of estrogen receptors | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |