Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TERT | O14746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601459 | 0.80 | CES2 (0.52) | KDM4ECES2CES1MEN1KMT2A | |
| SCHEMBL5954123 | 0.79 | CTNNB1 (0.49) | KDM4ECES2CES1MEN1KMT2A | |
| SCHEMBL24693246 | 0.76 | MEN1 (0.38) | KDM4ECES2CES1MEN1KMT2A | |
| SCHEMBL1162543 | 0.75 | CES2 (0.56) | CES2CES1MEN1KMT2ATDP1 | |
| SCHEMBL12934272 | 0.74 | CES2 (0.50) | KDM4ECES2CES1MEN1KMT2A | |
| SCHEMBL5954012 | 0.74 | HTR7 (0.61) | KDM4EKMT2AALDH1A1MAPTPOLB | |
| SCHEMBL28910438 | 0.74 | CES2 (0.54) | KDM4ECES2CES1MEN1KMT2A | |
| SCHEMBL6322827 | 0.73 | KMT2A (0.67) | KDM4ECES1MEN1KMT2ATDP1 | |
| SCHEMBL2088179 | 0.72 | CES2 (0.52) | KDM4ECES2CES1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10670271 | 0.71 | KMT2A (0.65) | KDM4ECES1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007136790-A2 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2007-11-29 | — | — | WO | disclosed |