Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1438239 | 0.97 | HRH3 (0.45) | HRH3FFAR1GRIN1GRIN2BKDM2B | |
| SCHEMBL1438821 | 0.93 | HRH3 (0.42) | HRH3FFAR1KDM2BS1PR1 | |
| SCHEMBL1438604 | 0.93 | HRH3 (0.41) | HRH3FFAR1GRIN1GRIN2BKDM2B | |
| SCHEMBL1438554 | 0.92 | THRB (0.43) | HRH3FFAR1GRIN1GRIN2BKDM2B | |
| SCHEMBL15484527 | 0.88 | DRD3 (0.46) | HRH3GRIN1GRIN2BKDM2BDRD3 | |
| SCHEMBL1439048 | 0.88 | HRH3 (0.41) | HRH3GRIN1GRIN2BKDM2BDRD3 | |
| SCHEMBL1438100 | 0.87 | EGFR (0.48) | FFAR1GRIN1GRIN2BKDM2BFFAR4 | |
| SCHEMBL1437924 | 0.87 | FFAR1 (0.44) | HRH3FFAR1GRIN1GRIN2BS1PR1 | |
| SCHEMBL1438702 | 0.87 | S1PR5 (0.48) | FFAR1GRIN1GRIN2BKDM2BS1PR1 | |
| SCHEMBL1438072 | 0.86 | GRIN1 (0.45) | HRH3FFAR1GRIN1GRIN2BFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473490-A1 | (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | Abbott Healthcare Products B.V. (NL) | 2012-07-11 | — | — | EP | claimed |
| WO-2011023795-A1 | (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2011-03-03 | — | — | WO | claimed |