Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 12/20 | 0.41 |
| ▸ | GSK3B | P49841 | 11/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039120 | 0.80 | DYRK1A (0.41) | DYRK1AGSK3BRBP4CLK2CLK3 | |
| SCHEMBL1176208 | 0.80 | DYRK1A (0.41) | DYRK1AGSK3BRBP4CLK2CLK3 | |
| SCHEMBL14390877 | 0.78 | PRKAB2 (0.43) | DYRK1AGSK3BRBP4MAPTMAPK1 | |
| SCHEMBL1572932 | 0.78 | DYRK1A (0.41) | DYRK1AGSK3B | |
| SCHEMBL14391089 | 0.78 | MAPT (0.46) | DYRK1AGSK3BRBP4MAPTMAPK1 | |
| SCHEMBL14391270 | 0.78 | MAPT (0.46) | DYRK1AGSK3BMAPTMAPK1CLK2 | |
| Formic Acid SCHEMBL5562792 | 0.77 | DYRK1A (0.39) | DYRK1AGSK3BRBP4CLK2CLK3 | |
| SCHEMBL14391094 | 0.75 | GSK3B (0.47) | DYRK1AGSK3BMAPTMAPK1 | |
| SCHEMBL14391202 | 0.75 | DYRK1A (0.42) | DYRK1AGSK3BMAPTMAPK1CLK2 | |
| SCHEMBL14391201 | 0.75 | HAO1 (0.38) | DYRK1AGSK3BMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | disclosed |