Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.42 |
| ▸ | WNT1 | P04628 | 5/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | CCNC | P24863 | 5/20 | 0.40 |
| ▸ | CDK8 | P49336 | 5/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14391270 | 0.89 | MAPT (0.46) | MAPTMAPK1DYRK1AWNT1GSK3B | |
| SCHEMBL14391073 | 0.81 | DYRK1A (0.44) | MAPTMAPK1DYRK1AWNT1CDK2 | |
| SCHEMBL14391091 | 0.80 | HAO1 (0.43) | MAPTMAPK1DYRK1AWNT1GSK3B | |
| SCHEMBL14390881 | 0.80 | GSK3B (0.55) | MAPTMAPK1DYRK1AWNT1GSK3B | |
| SCHEMBL5042826 | 0.78 | DYRK1A (0.39) | MAPTMAPK1DYRK1AWNT1GSK3B | |
| SCHEMBL2006524 | 0.78 | DYRK1A (0.39) | MAPTMAPK1DYRK1AWNT1GSK3B | |
| SCHEMBL14390878 | 0.78 | DYRK1A (0.41) | MAPTMAPK1DYRK1AGSK3BRBP4 | |
| SCHEMBL14390877 | 0.77 | PRKAB2 (0.43) | MAPTMAPK1DYRK1AGSK3BCCNC | |
| SCHEMBL14391202 | 0.74 | DYRK1A (0.42) | MAPTMAPK1DYRK1AWNT1GSK3B | |
| SCHEMBL14391094 | 0.74 | GSK3B (0.47) | MAPTMAPK1DYRK1AWNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | disclosed |