Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | LTK | P29376 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | PRKX | P51817 | 1/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | MST1R | Q04912 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14614929 | 0.81 | PTGES (0.59) | CDK5PLK4CHEK1AURKADAPK3 | |
| SCHEMBL261542 | 0.78 | HTR3A (0.55) | KCNH2 | |
| SCHEMBL261350 | 0.78 | HTR3A (0.55) | KCNH2 | |
| SCHEMBL261358 | 0.78 | HTR3A (0.55) | KCNH2 | |
| SCHEMBL28917070 | 0.78 | CDK2 (0.56) | CDK5PLK4CHEK1AURKADAPK3 | |
| Hydrochloric Acid SCHEMBL261622 | 0.77 | HTR3A (0.54) | KCNH2 | |
| Hydrochloric Acid SCHEMBL261195 | 0.77 | HTR3A (0.54) | KCNH2 | |
| Hydrochloric Acid SCHEMBL261061 | 0.77 | HTR3A (0.54) | KCNH2 | |
| SCHEMBL23185459 | 0.76 | PLK4 (0.50) | CDK5PLK4CHEK1AURKADAPK3 | |
| SCHEMBL8359202 | 0.74 | PARP1 (0.48) | CDK5PLK4CHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007125405-A2 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-08 | — | — | WO | disclosed |