Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 19/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.44 |
| ▸ | CDK2 | P24941 | 6/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11931187 | 0.90 | GSK3B (0.54) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931183 | 0.79 | GSK3B (0.51) | GSK3BCHEK1 | |
| SCHEMBL13998548 | 0.72 | GSK3B (0.73) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931165 | 0.71 | GSK3B (0.44) | GSK3BCDK2 | |
| SCHEMBL11931185 | 0.71 | GSK3B (0.54) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13305295 | 0.70 | GSK3B (0.81) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL12953000 | 0.70 | GSK3B (1.00) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13146283 | 0.70 | GSK3B (0.81) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931084 | 0.69 | CHEK1 (0.84) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13911623 | 0.69 | SLC40A1 (0.40) | GSK3BCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534710-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-10-24 | — | — | EP | disclosed |