Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 4/20 | 0.40 |
| ▸ | KLF5 | Q13887 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 8/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097418 | 0.90 | ABL1 (0.49) | ABL1 | |
| SCHEMBL14395645 | 0.84 | CYP3A4 (0.51) | SMN1; SMN2MEN1KMT2APOLBHTT | |
| SCHEMBL14097403 | 0.71 | ABL1 (0.60) | ABL1 | |
| SCHEMBL20685386 | 0.71 | MTOR (0.52) | SMN1; SMN2MEN1KMT2AHTTABL1 | |
| SCHEMBL14395370 | 0.69 | ABL1 (0.51) | ABL1 | |
| SCHEMBL13350140 | 0.68 | LCK (0.55) | SMN1; SMN2MEN1KMT2APOLBHTT | |
| SCHEMBL6784411 | 0.68 | LCK (0.57) | SMN1; SMN2MEN1KMT2AHTTNPC1 | |
| SCHEMBL12393042 | 0.68 | LCK (0.57) | SMN1; SMN2MEN1KMT2AHTTNPC1 | |
| SCHEMBL6791011 | 0.67 | LCK (0.56) | SMN1; SMN2MEN1KMT2AHTTNPC1 | |
| SCHEMBL12392436 | 0.66 | RAB9A (0.51) | SMN1; SMN2MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341769-B1 | BACTERIAL GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2007-10-17 | — | — | EP | disclosed |