Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 9/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 9/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14456088 | 0.90 | MEN1 (0.44) | MEN1KMT2AMAPTMAPK1ATM | |
| SCHEMBL5271241 | 0.87 | HSP90AA1 (0.49) | MEN1KMT2AMAPTMAPK1NPSR1 | |
| SCHEMBL14456080 | 0.84 | MEN1 (0.67) | MEN1KMT2AMAPTMAPK1ATM | |
| SCHEMBL4885229 | 0.84 | MEN1 (0.48) | MEN1KMT2AMAPTMAPK1ATM | |
| SCHEMBL4884535 | 0.83 | MEN1 (0.52) | MEN1KMT2AMAPTMAPK1ATM | |
| SCHEMBL14456083 | 0.81 | HSP90AA1 (0.51) | MEN1KMT2AMAPTMAPK1ATM | |
| SCHEMBL5272655 | 0.79 | MEN1 (0.45) | MEN1KMT2AMAPTMAPK1ATM | |
| SCHEMBL14396113 | 0.79 | MEN1 (0.61) | MEN1KMT2AMAPTNPSR1POLB | |
| SCHEMBL14456096 | 0.78 | MAPT (0.72) | MEN1KMT2AMAPTMAPK1ATM | |
| SCHEMBL9818693 | 0.75 | PGR (0.49) | MEN1KMT2AMAPTATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456180-B1 | 3-(2,4)DIHYDROXYPHENYL-4-PHENYLPYRAZOLES AND THEIR MEDICAL USE | VERNALIS CAMBRIDGE LTD (GB) | 2007-10-03 | — | — | EP | disclosed |
| US-7247734-B2 | 3,4-diarylpyrazoles and their use in the therapy of cancer | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-07-24 | — | — | US | disclosed |