Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 5/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924418 | 0.85 | OGA (0.40) | KDRFGFR1EPHB4CCNT1CCNA2 | |
| SCHEMBL3927808 | 0.84 | NPC1 (0.36) | AURKAKDRFGFR1EPHB4HDAC3 | |
| SCHEMBL14396494 | 0.75 | MAPK8 (0.40) | AURKAKDRFGFR1CCNT1CCNA2 | |
| SCHEMBL3933161 | 0.75 | DPP4 (0.34) | SYKMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL14396485 | 0.73 | EPHB4 (0.40) | KDRFGFR1EPHB4PARP1 | |
| SCHEMBL3925451 | 0.73 | DPP4 (0.33) | — | |
| SCHEMBL14395973 | 0.72 | BRD4 (0.33) | — | |
| SCHEMBL5317345 | 0.71 | CCNT1 (0.44) | KDRFGFR1EPHB4MEN1KMT2A | |
| SCHEMBL3924707 | 0.69 | MKNK1 (0.45) | KDRFGFR1CCNT1CCNA2CDK2 | |
| SCHEMBL3935077 | 0.68 | MAP3K5 (0.41) | KDRFGFR1EPHB4CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | disclosed |