Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EIF4E | P06730 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371510 | 0.91 | GAA (0.59) | POLBGAACSNK2A1FOLH1METAP2 | |
| SCHEMBL4621112 | 0.85 | CSNK2A1 (0.65) | POLBGAACSNK2A1METAP2TTR | |
| SCHEMBL1775360 | 0.84 | MCL1 (0.53) | POLBGAACSNK2A1FOLH1METAP2 | |
| SCHEMBL9223049 | 0.83 | CYP3A4 (0.60) | GAAFOLH1KDM4CALDH1A1MYC | |
| SCHEMBL6702122 | 0.82 | MYC (0.58) | POLBGAACSNK2A1FOLH1ALDH1A1 | |
| SCHEMBL28926811 | 0.81 | GAA (0.54) | POLBGAACSNK2A1FOLH1TTR | |
| SCHEMBL18364471 | 0.81 | FOLH1 (0.49) | FOLH1KDM4CTTRALDH1A1EIF4E | |
| SCHEMBL3733709 | 0.80 | HDAC7 (0.60) | POLBCSNK2A1FOLH1METAP2TTR | |
| SCHEMBL978600 | 0.79 | KDM4C (0.50) | POLBKDM4CMEN1ALDH1A1KMT2A | |
| SCHEMBL2563725 | 0.79 | EIF4E (0.47) | POLBGAACSNK2A1FOLH1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117180-A1 | AZAHETEROCYCLES, COMBINATORY LIBRARY, FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION AND METHODS FOR THE PRODUCTION THEREOF | 'CHEMICAL DIVERSITY RESEARCH INSTITUTE' LTD. (RU) | 2007-10-18 | — | — | WO | disclosed |