SCHEMBL3733709

SCHEMBL3733709

Cc1ccc(-c2ccccc2)c(C(=O)O)c1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC7 Q8WUI4 1/20 0.60
FOLH1 Q04609 1/20 0.57
HSD17B10 Q99714 2/20 0.55
ALDH1A1 P00352 2/20 0.55
KDM4E B2RXH2 1/20 0.55
CSNK2A1 P68400 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
DHODH Q02127 1/20 0.49
POLB P06746 1/20 0.49
CYP46A1 Q9Y6A2 1/20 0.49
PTGDR2 Q9Y5Y4 1/20 0.49
LDHA P00338 1/20 0.49
PTPN1 P18031 1/20 0.49
FABP3 P05413 1/20 0.48
FABP4 P15090 1/20 0.48
METAP2 P50579 1/20 0.47
TTR P02766 1/20 0.47
HNF4A P41235 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6495696 0.90 HSD17B10 (0.58) HDAC7FOLH1HSD17B10ALDH1A1KDM4E
SCHEMBL8076238 0.89 CYP46A1 (0.67) HDAC7FOLH1HSD17B10ALDH1A1KDM4E
SCHEMBL9271820 0.87 HDAC7 (0.58) HDAC7FOLH1HSD17B10ALDH1A1KDM4E
SCHEMBL4621112 0.86 CSNK2A1 (0.65) HDAC7HSD17B10ALDH1A1KDM4ECSNK2A1
SCHEMBL7079259 0.85 HDAC7 (0.57) HDAC7FOLH1HSD17B10ALDH1A1KDM4E
SCHEMBL29135010 0.85 BCAT2 (0.61) HDAC7HSD17B10ALDH1A1KDM4ESMN1; SMN2
SCHEMBL27438916 0.85 HDAC7 (0.57) HDAC7FOLH1HSD17B10ALDH1A1KDM4E
SCHEMBL4371510 0.85 GAA (0.59) HDAC7FOLH1ALDH1A1KDM4ECSNK2A1
SCHEMBL3229733 0.85 HDAC7 (0.70) HDAC7HSD17B10ALDH1A1KDM4ECSNK2A1
SCHEMBL4366968 0.84 FOLH1 (0.62) FOLH1CSNK2A1DHODHPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108906-A Novel method for preparing 4 '-bromomethyl- [1,1' -biphenyl ] -2-tert-butyl formate 临海市华南化工有限公司 2022-09-27 CN claimed
CN-109890365-A The composition of small molecule therapy immunomodulator compounds 戴尔普尔有限公司 2019-06-14 CN claimed
CN-105037134-A Asymmetric diphenic acid isomeride separation method Qidong dongyue pharmaceutical co ltd 2015-11-11 CN claimed
CN-115108906-A Novel method for preparing 4 '-bromomethyl- [1,1' -biphenyl ] -2-tert-butyl formate 临海市华南化工有限公司 2022-09-27 CN disclosed
CN-114502132-A Near-infrared blocking agent and near-infrared blocking skin preparation for external use 东洋美妆株式会社 2022-05-13 CN disclosed
CN-114436833-A Preparation method of telmisartan key intermediate 4' -methylbiphenyl-2-carboxylic ester 南京红太阳医药研究院有限公司 2022-05-06 CN disclosed
CN-110862368-B Photocatalytic oxidation synthesis method of benzocoumarin compound 浙江工业大学 2021-06-15 CN disclosed
EP-3713910-A1 METHOD FOR THE METAL-FREE PREPARATION OF A BIARYL BY A PHOTOSPLICING REACTION AND THEIR USES Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- (HKI) (DE) 2020-09-30 EP disclosed
CN-110862368-A Photocatalytic oxidation synthesis method of benzocoumarin compound 浙江工业大学 2020-03-06 CN disclosed
CN-110372511-A Utilize the method for 4 '-methyl biphenyl -2- carboxylate methyl ester waste residues preparation high-purity 4 '-methyl biphenyl -2- carboxylate methyl ester 河南华商药业有限公司 2019-10-25 CN disclosed
EP-2906553-B1 OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES IDORSIA PHARMACEUTICALS LTD (CH) 2019-06-26 EP disclosed
WO-2002028835-A1 BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-04-11 WO disclosed
EP-1044958-A1 PROCESS FOR PRODUCING tert-BUTYL 4'-METHYL-2-BIPHENYLCARBOXYLATE SUMIKA FINE CHEMICALS Co., Ltd. (JP) 2000-10-18 EP disclosed
EP-1019048-A1 USE OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE PREPARATION OF DRUGS TO INCREASE THE SURVIVAL RATE OF RENAL TRANSPLANT PATIENTS Merck Sharp Dohme (Italia) S.P.A. (IT) 2000-07-19 EP disclosed
WO-1999016437-A1 USE OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE PREPARATION OF DRUGS TO INCREASE THE SURVIVAL RATE OF RENAL TRANSPLANT PATIENTS MERCK SHARP DOHME (ITALIA) S.P.A. (IT) 1999-04-08 WO disclosed
US-5736555-A HYPOTENSIVE AGENTS; FDA ORANGE BOOK LISTED PATENT FOR AZILSARTAN MEDOXOMIL TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-04-07 US disclosed
WO-1998006688-A1 CATALYSED COUPLING OF ARYL MAGNESIUM HALOGENIDES AND BROMARYL CARBOXYLIC ACID COMPOUNDS FOR PREPARING BIPHENYL CARBOXYLIC ACIDS GREAT LAKES CHEMICAL KONSTANZ GMBH (DE) 1998-02-19 WO disclosed
US-5243054-A Hypotensive agents, cardiovascular disorders or nervous system disorders TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-09-07 US disclosed
US-4188274-A DECARBOXYLATION STANDARD OIL COMPANY (INDIANA) (US) 1980-02-12 US disclosed
US-4174447-A SILVER SALTS OF CARBOXY ACIDS STANDARD OIL COMPANY (INDIANA) (US) 1979-11-13 US disclosed