Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | GRIA1 | P42261 | 8/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462766 | 0.86 | GRIN2D (0.70) | ALDH1A1TDP1GRIA1GRIN2DGRIN3B | |
| SCHEMBL3786399 | 0.83 | PDE3B (0.50) | ALDH1A1TDP1GRIA1GRIN2DGRIN3B | |
| SCHEMBL640124 | 0.83 | GRIA1 (0.70) | ALDH1A1GRIA1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8137325 | 0.82 | ALDH1A1 (0.47) | ALDH1A1TDP1GRIA1GRIN2DGRIN3B | |
| SCHEMBL29909816 | 0.82 | ALDH1A1 (0.47) | ALDH1A1TDP1GRIA1GRIN2DGRIN3B | |
| SCHEMBL17432052 | 0.77 | ALDH1A1 (1.00) | ALDH1A1TDP1GRIA1GRIN2DGRIN3B | |
| SCHEMBL1115539 | 0.73 | GRIA1 (0.50) | ALDH1A1GRIA1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL22725084 | 0.73 | MAPT (0.42) | ALDH1A1TDP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL17758383 | 0.73 | PDE3B (0.41) | ALDH1A1TDP1GRIA1GRIN2DGRIN3B | |
| SCHEMBL31748445 | 0.73 | MAPT (0.42) | ALDH1A1TDP1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |