Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31748445 | 1.00 | MAPT (0.42) | MAPTALDH1A1LMNAHTTRAB9A | |
| SCHEMBL463673 | 0.86 | GRIN2D (0.52) | MAPTALDH1A1LMNASMN1; SMN2GRIN2D | |
| SCHEMBL3786399 | 0.83 | PDE3B (0.50) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL29909400 | 0.82 | ALDH1A1 (0.47) | MAPTALDH1A1LMNAHTTRAB9A | |
| SCHEMBL30504341 | 0.82 | KDM4E (0.47) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL25201307 | 0.82 | KDM4E (0.47) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL2731858 | 0.82 | ALDH1A1 (0.47) | MAPTALDH1A1LMNAHTTRAB9A | |
| SCHEMBL23172280 | 0.75 | IDO1 (0.37) | ALDH1A1SMN1; SMN2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL16738736 | 0.73 | EPAS1 (0.49) | MAPTALDH1A1PDE3BPDE3AGRIN2D | |
| SCHEMBL19644507 | 0.73 | GRIA1 (0.50) | MAPTALDH1A1LMNAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
| WO-2020240492-A1 | 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2020-12-03 | — | — | WO | disclosed |