Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11686502 | 0.79 | HTT (0.71) | HTTHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14283719 | 0.75 | HTT (0.65) | HTTHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14283722 | 0.75 | HTT (0.65) | HTTHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14308366 | 0.75 | HTT (0.65) | HTTHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1266791 | 0.75 | HTT (1.00) | HTTHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL5535871 | 0.73 | HTT (0.97) | HTTHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5532426 | 0.72 | HTT (0.61) | HTTHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27051953 | 0.71 | HTT (0.48) | HTTHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL24615662 | 0.68 | HTT (0.56) | HTTHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5533851 | 0.68 | HTT (0.82) | HTTHSD17B10SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232571-A1 | Novel Heteroaromatic Inhibitors of Fructose-1,6-Bisphosphatase | METABASIS THERAPEUTICS, INC. (US) | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232571-A1 | Novel Heteroaromatic Inhibitors of Fructose-1,6-Bisphosphatase | FBP1, ALDOA, G6PC1 | HTT 4548/4885HSD17B10 497/4885SMN1; SMN2 4562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.