Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 17/20 | 0.49 |
| ▸ | KIT | P10721 | 9/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.38 |
| ▸ | LCK | P06239 | 4/20 | 0.38 |
| ▸ | AXL | P30530 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | STK25 | O00506 | 2/20 | 0.38 |
| ▸ | RIOK3 | O14730 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | GAK | O14976 | 2/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.38 |
| ▸ | MUSK | O15146 | 2/20 | 0.38 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | MAP3K13 | O43283 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14401644 | 0.86 | CSF1R (0.65) | CSF1RKITNTRK1LCKAXL | |
| SCHEMBL2177426 | 0.85 | CSF1R (0.54) | CSF1RKITCYP2C19CYP3A4 | |
| SCHEMBL12408095 | 0.76 | CSF1R (0.46) | CSF1RKITCYP2C19CYP3A4 | |
| SCHEMBL14117099 | 0.75 | CSF1R (0.54) | CSF1RKITNTRK1LCKAXL | |
| SCHEMBL1856316 | 0.73 | CSF1R (0.57) | CSF1RKITNTRK1LCKAXL | |
| SCHEMBL14401662 | 0.73 | CSF1R (0.52) | CSF1RKITNTRK1LCKAXL | |
| SCHEMBL4323858 | 0.70 | CSF1R (0.40) | CSF1R | |
| SCHEMBL1856332 | 0.70 | CSF1R (0.72) | CSF1RKITCYP2C19 | |
| SCHEMBL12487348 | 0.70 | CSF1R (0.68) | CSF1RKITNTRK1LCKAXL | |
| SCHEMBL14117231 | 0.67 | CSF1R (0.67) | CSF1RKITNTRK1LCKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249593-A1 | e.g. 4-Cyano-1H-imidazole-2-carboxylic acid [2-cyclohex-1-enyl-4-(2,6-dioxo-piperidin-4-yl)-phenyl]-amide; tyrosine kinase inhibitor; autoimmune diseases, antiinflammatory, anticarcinogenic agent | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249593-A1 | e.g. 4-Cyano-1H-imidazole-2-carboxylic acid [2-cyclohex-1-enyl-4-(2,6-dioxo-piperidin-4-yl)-phenyl]-amide; tyrosine kinase inhibitor; autoimmune diseases, antiinflammatory, anticarcinogenic agent | MUSK, CHUK, PNCK | CSF1R 249/4885KIT 119/4885NTRK1 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.