Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144344 | 0.95 | ABCB1 (0.45) | ABCB1ABCG2MAPTALDH1A1POLB | |
| SCHEMBL146879 | 0.92 | MAPK1 (0.47) | ABCB1ABCG2MAPTALDH1A1POLB | |
| SCHEMBL147544 | 0.90 | LMNA (0.51) | ABCB1ABCG2MAPTALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL7650133 | 0.89 | LMNA (0.50) | ABCB1ABCG2MAPTALDH1A1POLB | |
| SCHEMBL143145 | 0.85 | ABL1 (0.51) | ABCB1ABCG2MAPTALDH1A1POLB | |
| SCHEMBL146882 | 0.85 | MAPK1 (0.46) | ABCB1ABCG2MAPTALDH1A1AAK1 | |
| Hydrochloric Acid SCHEMBL7652761 | 0.84 | MAPK1 (0.45) | ABCB1ABCG2MAPTALDH1A1AAK1 | |
| SCHEMBL145065 | 0.84 | PDE4A (0.51) | ABCB1ABCG2MAPTALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL7646226 | 0.84 | PDE4D (0.50) | ABCB1ABCG2MAPTALDH1A1POLB | |
| SCHEMBL6603434 | 0.83 | LMNA (0.50) | ABCB1ABCG2ALDH1A1AAK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |