Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL147488 | 0.99 | LMNA (0.49) | LMNATSHRSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL146882 | 0.94 | MAPK1 (0.46) | LMNATSHRSMN1; SMN2ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL7652761 | 0.93 | MAPK1 (0.45) | LMNATSHRSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL147544 | 0.92 | LMNA (0.51) | LMNASMN1; SMN2ALDH1A1GAAAAK1 | |
| SCHEMBL145758 | 0.92 | PDE5A (0.49) | LMNATSHRSMN1; SMN2ALDH1A1PDE4B | |
| Hydrochloric Acid SCHEMBL7650133 | 0.92 | LMNA (0.50) | LMNASMN1; SMN2ALDH1A1GAAAAK1 | |
| SCHEMBL6602100 | 0.91 | MAOB (0.48) | LMNASMN1; SMN2ALDH1A1PDE4BMAOB | |
| Hydrochloric Acid SCHEMBL7646213 | 0.91 | MAOB (0.47) | LMNASMN1; SMN2ALDH1A1PDE4BMAOB | |
| SCHEMBL6602109 | 0.89 | RAB9A (0.53) | LMNASMN1; SMN2ALDH1A1MAOBKDM4E | |
| SCHEMBL6602165 | 0.88 | MAOB (0.48) | LMNASMN1; SMN2ALDH1A1PDE4BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1578665-A | Type 4 phosphodiesterase inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2005-02-09 | — | — | CN | claimed |
| CN-1578665-A | Type 4 phosphodiesterase inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2005-02-09 | — | — | CN | disclosed |
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| EP-1143944-A3 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2002-09-11 | — | — | EP | disclosed |
| EP-1143944-A2 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000059484-A2 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2000-10-12 | — | — | WO | disclosed |
| EP-0922036-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GmbH (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006704-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |