Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PTGES | O14684 | 11/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1440737 | 0.96 | MAPT (0.56) | MAPTPTGESTSHRLMNATP53 | |
| SCHEMBL1440380 | 0.92 | PTGES (0.58) | MAPTPTGESTSHRLMNATP53 | |
| SCHEMBL1440054 | 0.92 | PTGES (0.52) | MAPTPTGESTSHRLMNATP53 | |
| SCHEMBL1440421 | 0.89 | PTGES (0.52) | MAPTPTGESTSHRLMNATP53 | |
| SCHEMBL1441498 | 0.88 | PTGES (0.48) | MAPTPTGESTSHRLMNATP53 | |
| SCHEMBL1440309 | 0.88 | MAPT (0.52) | MAPTPTGESLMNATP53 | |
| SCHEMBL1440314 | 0.88 | MAPT (0.52) | MAPTPTGESLMNATP53 | |
| SCHEMBL1441243 | 0.87 | MAPT (0.52) | MAPTPTGESLMNATP53PTGS2 | |
| SCHEMBL1439975 | 0.86 | PTGES (0.48) | MAPTPTGESTSHRLMNATP53 | |
| SCHEMBL1440776 | 0.84 | MAPT (0.55) | MAPTLMNATP53HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |